Last edited by Vik
Sunday, October 11, 2020 | History

2 edition of Characterization of the ionizing radiation-inducible gene O6-methylguanine DNA methyltransferase and its role in radiation responses . found in the catalog.

Characterization of the ionizing radiation-inducible gene O6-methylguanine DNA methyltransferase and its role in radiation responses .

Lindsay Jane Park

Characterization of the ionizing radiation-inducible gene O6-methylguanine DNA methyltransferase and its role in radiation responses .

by Lindsay Jane Park

  • 87 Want to read
  • 24 Currently reading

Published .
Written in English


About the Edition

O6-methylguanine DNA methyltransferase (MGMT) is a critical cellular resistance factor against the mutagenic and cytotoxic effects of O6-methylguanine (O6meG) DNA lesions, and via their repair, confers resistance to alkylating agents including several chemotherapeutic drugs. This study investigates the regulation of MGMT by ionizing radiation (IR) and its potential functional role in radiation responses. The present work indicates that the role of MGMT in radiation responses does not involve its classic O6meG repair function. Expression and enzymatic activity analyses show that MGMT is up-regulated by IR over a range of 0.5 to 20 Gy with delayed and long-lasting kinetics in several cell lines in vitro, and in all normal and malignant tissues examined in vivo. This has implications for cancer patients receiving combination modality treatment, where the induction of MGMT by initial radiation therapy could result in altered sensitivity of the tumour or normal surrounding tissues to subsequent chemotherapy.

The Physical Object
Pagination118 leaves.
Number of Pages118
ID Numbers
Open LibraryOL19512765M
ISBN 100612954811


Share this book
You might also like
Information at work

Information at work

Anglicko-slovenský slovník

Anglicko-slovenský slovník

United Nations Development Programme, development of the Sittang River Valley, Burma

United Nations Development Programme, development of the Sittang River Valley, Burma

Maoists in Nepal

Maoists in Nepal

Sexual feeling in married men and women.

Sexual feeling in married men and women.

My trust is in Thee [for] SAB and organ.

My trust is in Thee [for] SAB and organ.

log to the Ohio River

log to the Ohio River

American middle school

American middle school

If You Were an Animal Doctor

If You Were an Animal Doctor

Contentious activism & inter-Korean relations

Contentious activism & inter-Korean relations

Lord Byrons marriage

Lord Byrons marriage

Crown jewel

Crown jewel

Some authors; a collection of literary essays, 1896-1916.

Some authors; a collection of literary essays, 1896-1916.

Providers handbook for assessing criminal conduct and substance abuse clients

Providers handbook for assessing criminal conduct and substance abuse clients

A grey-cap, for a green-head

A grey-cap, for a green-head

Characterization of the ionizing radiation-inducible gene O6-methylguanine DNA methyltransferase and its role in radiation responses by Lindsay Jane Park Download PDF EPUB FB2